Structure Elucidation and Absolute Configuration of Megastigmane Derivatives from Cissus quadrangularis Linn

Three megastigmane derivatives, (6R, 7Z)-9,10-dihydroxy-4,7-megastigmadien-3-one, (6S,7E)-6,9,10trihydroxy-4,7-megastigmadien-3-one 6-O-β-D-glucopyranoside and (5R, 6S, 7E)-6, 9, 10-trihydroxy-7megastigmane-3-one 9-O-β-D-glucopyranoside, along with fourteen known compounds, were isolated from an ethanolic extract of Cissus quadrangularis Linn. The structures of the megastigmane derivatives were established via extensive spectroscopic analysis, while electronic circular dichroism (CD) was employed to determine their absolute configurations. Compounds are reported for the first time for C. quadrangularis. The isolated compounds were tested for antimicrobial and antiprotozoal activities.